Floating tablet of Torsemide (F) were prepared by direct compression technique. Torsemide was chosen as model drug because it is poorly soluble or water insoluble and poorly absorb from lower intestine. PEG-6000 is used as complexing agent for increasing solubility of Torsemide in water.Hydroxypropylmethylcellulose, sodium bicarbonate and carbapole were used as Matrixing agent gasgenerating agent and floating enhancers respectively. The tablets were evaluated for in-vitro buoyancy and dissolution studies Tablets were evaluated for physical characteristic viz. hardness, floating capacity thickness, swelling index, and weight variation. Further, tablets were evaluated for in vitro release characteristic for 8 hrs. The data of in-vitro dissolution study shows that the zero order plots were found to be fairly linear as indicated by their high regression value (R2=0.9772 to 0.9911). To confirm the exact mechanism of drug release from different formulation, the data was fitted to Korsmeyer Peppas equation. Regression values were from 0.9862 to 0.9963 which indicates linearity.
Loading....